Studies show that a new toothbrush is 30% more effective at removing the plaque on your teeth, so remember to replace your toothbrush every 3-4 months. Other times you should replace your toothbrush is if you notice the bristles are getting worn, which can cause gum damage, and after experiencing a cold or flu. Keep a watchful eye on children’s toothbrushes. Since they brush with uneven strokes, and even bite the bristles, they can get worn much faster. 
Stock up! Many groceries stores will have sales on your favorite brands of toothbrushes. Stock up so when you see your bristles going, you have a new one ready to go!
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Photo by Bookis Smuin on Flickr